Academic Degree(s)

M.D., Ph.D.

 

E-mail

carmine.pariante@kcl.ac.uk 

 

Current Position

• Professor in Biological Psychiatry and Head of Section, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London (from 1^st April 2012)
• NIHR Senior Investigator (from 1^st of April 2017)       
• Consultant in the Perinatal Psychiatry Liaison Services, King’s College Hospital & South London and Maudsley NHS Trust (from 1^st of August 2008)
• HEFCE-funded, 70%; NHS-funded, 30%; Clinically qualified, clinically active

 

Professional Experience

• 1991-1994 Trainee in Psychiatry, University of Cagliari, Italy
• 1995-1997 Research Fellow in Biological Psychiatry, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
• 1997-1999 Senior House Officer in Psychiatry, Maudsley Hospital, London
• 1999-2002 Medical Research Council Clinical Training Fellow, Institute of Psychiatry, London
• 2002-2004 Clinical Lecturer, Institute of Psychiatry, London
• 2004-2007 Senior Clinical Lecturer, Institute of Psychiatry, London
• 2004-2009 Medical Research Council Clinician Scientist, Institute of Psychiatry, London
• 2007-2012 Reader in Biological Psychiatry and Head of Section, Institute of Psychiatry, London

 

Education & Training

• 1990 MD in Medicine and Surgery, Cum Laude Gemelli University School of Medicine, Rome, Italy
• 1994 Specialist in Psychiatry, Cum Laude, University of Cagliari, Italy
• 1999 MRCPsych, Royal College of Psychiatry, London; Section 12 approval
• 2003 PhD, University of London
• 2004 Certificate of Completion of Specialist Training in General Adult Psychiatry, Endorsement in Liaison Psychiatry, London Deanery, UK
• 2013 FRCPsych, Royal College of Psychiatry, London

 

Awards

• 2002 British Association for Psychopharmacology & Vernalis Annual Prize
• 2003, 2005 NARSAD Young Investigator Award
• 2003 International Society of Psychoneuroendocrinology “Curt Richter Award”
• 2007 Young Minds in Psychiatry Award by the American Psychiatric Institute
• 2009 British Association for Psychopharmacology Senior Psychopharmacology Award
• 2012 Academic Psychiatrist of the Year by the Royal College of Psychiatrists, UK
• 2013 British Association for Psychopharmacology Public Communication Award
• 2015 Anna-Monika Foundation Prize
• 2016 Psychoneuroimmunology Research Society ‘Norman Cousins Award’
• 2017 President Elect, International Society for Psychoneuroendocrinology (ISPNE)
• 2017 Andrea Leadsom Award for Outstanding Contribution to Infant Mental Health
• 2017 NARSAD Distinguished Investigator Award
• 2017 NIHR Senior Investigator

 

Research Grants

• Wellcome Trust 01/01/2015-01/06/2018 £1,200,000, To investigate neuroimmunology of depression using PET, MRI and biomarkers (KCL)
• UK Medical Research Council/Eranet 01/04/2016-31/03/2019 £160,000, To investigate nutritional effects on mood and cognition
• 2012 NIHR BRC Theme Leader 01/04/2014-31/03/2017 £1,950,000, To conduct resear04ch on depression, anxiety and interface with medicine
• 2017 NIHR BRC Theme Leader 01/04/2017-31/03/2021 £3,250,000, To conduct research on depression, anxiety and interface with medicine
• NARSAD Distinguished Investigator 01/03/2018-28/02/2019 £70,000, To investigate genetic determinants of inflammation in depression       
• Psychiatry Research Trust 01/10/2018-30/09/2021 £100,000, To study the effects of inflammation in the perinatal period

 

Committee & Membership

• Editor-in-Chief, Brain, Behavior, and Immunity

 

Selected Publication

Professor Pariante has 275 publications listed in PubMed, totaling more than 13,900 citations, and leading to an h-index of 64 (Scopus, March 2018). Moreover, he has edited 6 books, including “Behavioral Neurobiology of Stress-related Disorders” (Springer, 2014). Full list of publications is available here: https://kclpure.kcl.ac.uk/portal/en/persons/carmine-pariante(8a5754e2-4b66-4c2f-b5f1-67c0ac58d7d0)/publications.html.

• Cattaneo A, Cattane N, Malpighi C, Czamara D, Suarez A, Eriksson JG, Lahti J, Mondelli V, Dazzan P, Räikkönen K, Binder EB, Riva MA, Pariante CM. FoxO1, A2M, and TGF-β1: three novel genes predicting depression in gene X environment interactions are identified using cross-species and cross-tissues transcriptomic and miRNomic analyses. Mol Psychiatry. 2018 Jan 4.
• Borsini A, Cattaneo A, Malpighi C, Thuret S, Harrison NA; MRC ImmunoPsychiatry Consortium, Zunszain PA, Pariante CM. Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent Mechanisms. Int J Neuropsychopharmacol. 2017 Oct 10.
• Barnes J, Mondelli V, Pariante CM. NPPR: Genetic Contributions of Inflammation to Depression. Neuropsychopharmacology. 2017 Jan;42(1):81-98.
• Cattaneo A, Ferrari C, Uher R, Bocchio-Chiavetto L, Riva MA; MRC ImmunoPsychiatry Consortium, Pariante CM. Absolute Measurements of Macrophage Migration Inhibitory Factor and Interleukin-1-β mRNA Levels Accurately Predict Treatment Response in Depressed Patients. Int J Neuropsychopharmacol. 2016 Sep 30;19(10).
• Hepgul N, Cattaneo A, Agarwal K, Baraldi S, Borsini A, Mondelli V, Nikkheslat N, Lopizzo N, Riva MA, Russell A, Hotopf M, Pariante CM. Transcriptomics in Interferon-α-Treated Patients Identifies Inflammation-, Neuroplasticity- and Oxidative Stress-Related Signatures as Predictors and Correlates of Depression. Neuropsychopharmacology  2016 Sep;41(10):2502-11
• Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, Mohr DC, Schatzberg AF. Major depressive disorder. Nat Rev Dis Primers. 2016 Sep 15;2:16065.
• Plant D, Pawlby S, Sharp D, Pariante CM. Prenatal Maternal Depression is Associated with Offspring Inflammation at 25 Years: A Prospective Longitudinal Cohort Study. Translational Psychiatry, 016 Nov 1;6(11):e936.
• Baumeister D, Akhtar R, Ciufolini S, Pariante CM, Mondelli V. Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Molecular Psychiatry. 2015 Jun 2.
• Egeland M, Zunszain PA, Pariante CM. Molecular mechanisms in the regulation of adult neurogenesis during stress. Nat Rev Neurosci. 2015 Apr;16(4):189-200.
• Nikkheslat N, Zunszain PA, Horowitz MA, Barbosa IG, Parker JA, Myint AM, Schwarz MJ, Tylee AT, Carvalho LA, Pariante CM. Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression. Brain Behav Immun. 2015 Aug;48:8-18.
• Horowitz MA, Wertz J, Zhu D, Cattaneo A, Musaelyan K, Nikkheslat N, Thuret S, Pariante CM, Zunszain PA. Antidepressant compounds can be both pro- and anti-inflammatory in human hippocampal cells. Int J Neuropsychopharmacol. 2014 Oct 31;18(3).
• Su KP, Lai HC, Yang HT, Su WP, Peng CY, Chang JP, Chang HC, Pariante CM. Omega-3 Fatty Acids in the Prevention of Interferon-Alpha-Induced Depression: Results from a Randomized, Controlled Trial. Biol Psychiatry. 2014 Jan 24.
• Anacker C, Cattaneo A, Musaelyan K, Zunszain PA, Horowitz M, Thuret S, Price J, Riva MA, Gennarelli M, Pariante CM. Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis. Proceedings of National Academy of Sciences, USA (PNAS), 2013, May 21;110(21):8708-13.
• Klengel T, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Mayberg HS, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Binder EB. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.        Nat Neurosci 2013 Jan;16(1):33-41.
• Carvalho LA, Torre JP, Papadopoulos AS, Poon L, Juruena MF, Markopoulou K, Cleare AJ, Pariante CM. Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system. Journal of Affective Disorders. 2013 May 15;148(1):136-40.
• Cattaneo A, Gennarelli M, Uher R, Breen G, Farmer A, Aitchison KJ, Craig IW, Anacker C, Zunsztain PA, McGuffin P, Pariante CM. Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline 'Predictors' and Longitudinal 'Targets'. Neuropsychopharmacology. 2013 Feb;38(3):377-85.