Deputy Director for Science, Head of the Laboratory of Translational Biopsychiatry, Department of Experimental and Clinical Neuroscience, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russian Federation.
Chief Scientist, Department of Neuroscience, Laboratory of Translational and Clinical Neuroscience, Novosibirsk State University, Novosibirsk, Russian Federation.
Professional Experience
1983 - 1988: Postgraduate Research Assistant, Laboratory Genetic Neuroendocrinology, Institute of Cytology and Genetics Siberian Branch of the USSR Academy of Sciences, Novosibirsk.
1989 - 2016: Research Associate, Senior Scientist, Laboratory of Genetic Neuroendocrinology, Laboratory of Behavioral Neurogenomics, Laboratory of Evolutionary Genetics, Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Novosibirsk.
2014 – present: Deputy Director for Science, Head of the Laboratory of Biological Psychiatry, Laboratory of Translational Biopsychiatry, Federal State Budgetary Scientific Institution “Scientific Research Institute of Physiology and Basic Medicine”, Novosibirsk.
Education & Training
M.S. Altai State University, Barnaul, Russia, 1983.
Ph.D., Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia, 1989.
D.Sci., Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia, 2006.
Research Grants
2015-2017 Russian Foundation for Basic Research (RFBR) - MOST, Taiwan Research Cooperation 15-54-52029 “Elucidating the mechanisms underlying neuroprotection and improvement of cognitive function with ceftriaxone treatment in PD animal models” (supervisor).
2012-2014 SB RAS, investigation grant “Nanobiosafety: the effects of nanoparticles at different levels of biological organization, from molecules to an organism” (supervisor).
2011-2013 Russian Foundation for Basic Research (RFBR) - NSC, Taiwan Research Cooperation 11-04-92009-ННС “Aging-induced neurodegeneration and behavioral deficits: evaluating the protective effects of diosgenin” (supervisor).
2010-2012 SB RAS, Russia - NSC, Taiwan Research Cooperation “Laser diagnostics of cancer using refraction measurements and fluorescence spectroscopy” (supervisor).
2009-2011 Russian Foundation for Basic Research (RFBR) investigation grant 09-04-00482: “Age-related aspects of neuroendocrine and neurochemical control of male sexual behavior in rats” (supervisor).
Committee & Membership
Japan Neuroscience Society
International “Stress and Behavior” Society
Member of editorial board THE CHINESE JOURNAL OF PHYSIOLOGY (2011 - 2014)
Selected Publication
Amstislavskaya TG, Maslova LN, Gladkikh DV, Belousova II, Stefanova NA, Kolosova NG. Effects of the mitochondria-targeted antioxidant SkQ1 on sexually motivated behavior in male rats. Pharmacol Biochem Behav. 2010 Aug;96(2):211-6. doi: 10.1016/j.pbb.2010.05.007.
Hung YT, Tikhonova MA, Ding SJ, Kao PF, Lan HH, Liao JM, Chen JH, Amstislavskaya TG, Ho YJ. Effects of chronic treatment with diosgenin on bone loss in a D-galactose-induced aging rat model. Chin J Physiol. 2014 Jun 30;57(3):121-7. doi: 10.4077/CJP.2014.BAC199.158.
Tikhonova MA, Yu CH, Kolosova NG, Gerlinskaya LA, Maslennikova SO, Yudina AV, Amstislavskaya TG, Ho YJ. Comparison of behavioral and biochemical deficits in rats with hereditary defined or D-galactose-induced accelerated senescence: evaluating the protective effects of diosgenin. Pharmacol Biochem Behav. 2014 May;120:7-16. doi: 10.1016/j.pbb.2014.01.012.159.
Ho SC, Hsu CC, Yu CH, Huang WN, Tikhonova MA, Ho MC, Hung CS, Amstislavskaya TG, Ho YJ. Measuring attention in a Parkinson's disease rat model using the 5-arm maze test. Physiol Behav. 2014 May 10;130:176-81. doi: 10.1016/j.physbeh.2014.03.017.161.
Ho SC, Hsu CC, Pawlak CR, Tikhonova MA, Lai TJ, Amstislavskaya TG, Ho YJ. Effects of ceftriaxone on the behavioral and neuronal changes in an MPTP-induced Parkinson's disease rat model. Behav Brain Res. 2014 Jul 15;268:177-84. doi: 10.1016/j.bbr.2014.04.022.162.
Jen CP, Amstislavskaya TG, Kuo CC, Chen YH. Protein preconcentration using nanofractures generated by nanoparticle-assisted electric breakdown at junction gaps. PLoS One. 2014 Jul 15;9(7):e102050. doi: 10.1371/journal.pone.0102050. eCollection 2014.
Lu KT, Huang TC, Wang JY, You YS, Chou JL, Chan MW, Wo PY, Amstislavskaya TG, Tikhonova MA, Yang YL. NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through CREB phosphorylation and HIF-1α expression. Pflugers Arch. 2015 Aug;467(8):1651-61. doi: 10.1007/s00424-014-1588-x.
Tikhonova MA, Romaschenko AV, Akulov AE, Ho YJ, Kolosova NG, Moshkin MP, Amstislavskaya TG. Comparative study of perception and processing of socially or sexually significant odor information in male rats with normal or accelerated senescence using fMRI. Behav Brain Res. 2015 Nov 1;294:89-94. doi: 10.1016/j.bbr.2015.08.001.
Tikhonova MA, Ting CH, Kolosova NG, Hsu CY, Chen JH, Huang CW, Tseng GT, Hung CS, Kao PF, Amstislavskaya TG, Ho YJ. Improving Bone Microarchitecture in Aging with Diosgenin Treatment: A Study in Senescence-Accelerated OXYS Rats. Chin J Physiol. 2015 Oct 31;58(5):322-31. doi: 10.4077/CJP.2015.BAD325.
Tikhonova MA, Amstislavskaya TG, Belichenko VM, Fedoseeva LA, Kovalenko SP, Pisareva EE, Avdeeva AS, Kolosova NG, Belyaev ND, Aftanas LI. Modulation of the expression of genes related to the system of amyloid-beta metabolism in the brain as a novel mechanism of ceftriaxone neuroprotective properties. BMC Neurosci. 2018 Apr 19;19(Suppl 1):13. doi: 10.1186/s12868-018-0412-5.
