Academic Degree(s)

Ph.D.

E-mail

hashimoto@faculty.chiba-u.jp

Current Position

• Professor, Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Japan

Professional Experience

• Academic Editor and Section Editor, PLOS ONE (2007 -)
• Editor, Eur. Arch. Psychiatry & Clin. Neurosci. (2015-)
• Principal Editor, Psychopharmacology (2017 -)

Education & Training

• 1988 PhD degree, Kyushu University (Fukuoka, Japan)
• 1991 – 1993 Visiting fellow, NIH/NIDA (Baltimore, MF, USA)

Research Grants

• JSPS grant, Japan (2017-2020)
• AMED grant, Japan (2016 -2020)

Committee & Membership

• Japanese Society of Biological Psychiatry (2017-)

Selected Publication

• Hashimoto K, Fukushima T, Shimizu E, Komatsu N, Watanabe H., Shinoda N, Nakazato M, Kumakiri C, Okada S, Hasegawa H, Imai K, Iyo M. Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the NMDA receptor hypofunction hypothesis of schizophrenia. Arch. Gen. Psychiatry 60:572-576, 2003.
• Hashimoto K, Tsukada H, Nishiyama S, Fukumoto D, Kakiuchi T, Iyo M. Protective effects of minocycline on the reduction of dopamine transporters in the striatum after administration of methamphetamine: A PET study in conscious monkeys.
• Biol. Psychiatry 61: 577-581, 2007.
• Hashimoto K, Sawa A, Iyo M. Increased levels of glutamate in brains from patients with mood disorders. Biol. Psychiatry 62: 1310-1316, 2007.
• Hashimoto K, Ishima T, Fujita Y, Matsuo M, Kobashi T, Takahagi M, Tsukada H, Iyo M. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective a7 nicotinic receptor agonist SSR180711.
• Biol. Psychiatry 63: 92-97, 2008.
• Hashimoto K, Fujita Y, Horio M, Kunitachi S, Iyo M, Ferraris D, Tsukamoto T. Co-administration of D-amino acid oxidase inhibitor potentiates the efficacy of D-serine on prepulse inhibition deficits after administration of dizocilpine. Biol. Psychiatry 65: 1103-1106, 2009.
• Yoshimi N, Futamura T, Bergen SE, Iwayama Y, Ishima T, Sellgren C, Ekman CJ, Jakobsson J, Pålsson E, Kakumoto K, Ohgi Y, Yoshikawa T, Landén M, Hashimoto K. Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: Evidence in support of mitochondrial dysfunction hypothesis. Mol. Psychiatry 21: 1504-1510, 2016.
• Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner K, Zhang JC, Yang C, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc. Natl. Acad. Sci. USA 113: E1944-E1952, 2016.
• Yang C, Ren Q, Qu Y, Zhang JC, Ma M, Dong C, Hashimoto K. Mechanistic target of rapamycin-independent antidepressant effects of (R)-ketamine in a social defeat stress model. Biol. Psychiatry 83: 18-28, 2018.
• Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa K, Kobayashi K, Muiayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. Soluble epoxide hydrolkase plays a key role in the pathogenesis of Parkinson’s disease. Proc. Natl. Acad. Sci. USA in press.
• Yang C, Kobayashi S, Nakao K, Dong C, Han M, Qu Y, Ren Q, Zhang JC, Ma M, Toki H, Yamaguchi J, Chaki S, Shirayama Y, Nakazawa K, Manabe T, Hashimoto K. AMPAR activation-independent antidepressant actions of ketamine metabolite (S)-norketamine. Biol. Psychiatry in press.